Niemann-Pick C1 Modulates Hepatic Triglyceride Metabolism and Its Genetic Variation Contributes to Serum Triglyceride Levels
نویسندگان
چکیده
منابع مشابه
Niemann-Pick C1 modulates hepatic triglyceride metabolism and its genetic variation contributes to serum triglyceride levels.
OBJECTIVE To study how Niemann-Pick disease type C1 (NPC1) influences hepatic triacylglycerol (TG) metabolism and to determine whether this is reflected in circulating lipid levels. METHODS AND RESULTS In Npc1(-/-) mice, the hepatic cholesterol content is increased but the TG content is decreased. We investigated lipid metabolism in Npc1(-/-) mouse hepatocytes and the association of NPC1 sing...
متن کاملNiemann-Pick Disease Type C1 Modulates Hepatic Triglyceride Metabolism and Its Genetic Variation Contributes to Serum Triglyceride Levels
to determine whether this is reflected in circulating lipid levels. Methods and Results—In Npc1 / mice, the hepatic cholesterol content is increased but the TG content is decreased. We investigated lipid metabolism in Npc1 / mouse hepatocytes and the association of NPC1 single-nucleotide polymorphisms with circulating TGs in humans. TGs were reduced in Npc1 / mouse serum and hepatocytes. In Npc...
متن کاملNiemann-Pick C1
So what does NPC1 really do? This is the key question. NPC1 shares significant structural homology with the resistance–nodulation–division (RND) family of permeases, members of which transport a number of substrates including heavy metals and lipids. Like its prokaryotic counterparts, NPC1 appears to transport fatty acids, but has not yet been shown to transport cholesterol. It has been suggest...
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mong the major components of the standard plasma lipid rofile, the total triglyceride (TG) level is generally considred the weakest risk factor for atherosclerosis, for which here are several likely contributing reasons. First, TG is eadily metabolized and is not a major constituent of therosclerotic plaque. Second, plasma TG varies greatly rom day to day in the fasting state and even more in t...
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ژورنال
عنوان ژورنال: Arteriosclerosis, Thrombosis, and Vascular Biology
سال: 2010
ISSN: 1079-5642,1524-4636
DOI: 10.1161/atvbaha.110.207191